公告内容

ADDF临床试验报告显示了从淀粉样方法的重大转变

2019年7月15日

分类:研究更新

The 老年痴呆症'的药物发现基金会(ADDF)发布了 a 新的临床试验分析 report 表明研究人员正在开发针对与衰老生物学相关的各种靶标的药物–超越传统的淀粉样蛋白和tau方法。

There are 102 potential treatments for 老年痴呆症's disease in clinical development with the majority (74%) focused on novel targets beyond amyloid and tau, according to the 报告. More than half (63%) of these potential treatments are in phase 2, when a drug is further evaluated for safety and tested for efficacy for the first time. ADDF has supported nearly 20% of these clinical-stage drugs.

随着领域转向这些新方法,正在研究的许多新疗法都集中在与衰老生物学相关的靶标上。该临床试验报告加强了最近发表于 神经病学®, which underscores a scientific strategy based on the biology of aging as an effective approach to prevent and treat 老年痴呆症's disease.

“鉴于衰老是阿尔茨海默氏症的主要危险因素'这种疾病,ADDF长期以来一直将注意力集中在更好地了解为何老化的大脑易患阿尔茨海默氏症's disease," said 医学博士霍华德·菲利特(Howard Fillit),ADDF的创始执行董事兼首席科学官。 “我们正在支持针对神经炎症,血管问题,突触丧失,代谢和线粒体功能障碍以及其他衰老故障的多种药物。”

Fillit博士指出,随着该领域开发更多的非淀粉样和非tau药物,生物标志物(生物过程的测量)对于推进临床研究至关重要。他解释说:“更便宜,更容易获得的生物标记物,例如验血,眼部扫描或数字工具,将有助于确保药物达到预定目标并在最有可能对药物产生反应的患者中进行检测。”

去年,ADDF创建了 诊断加速器, 一种 $50 million 由主要慈善家(包括 Leonard Lauder, Bill Gates, Jeff and MacKenzie Bezos, among others, to fast track the development of biomarkers and diagnostic tools for 老年痴呆症'疾病和相关的痴呆症,并有助于推进更具针对性的治疗方法的开发。

"老年痴呆症's is a complicated disease that can be caused by many factors," added Dr. Fillit. "Like other diseases of aging including cancer, diabetes and heart disease, it is likely a combination of drugs addressing multiple target pathways will be needed to effectively treat 老年痴呆症's。目标是通过精密医学进行联合治疗。”

ADDF's survey of the clinical trial landscape of 老年痴呆症'的药物基于联邦网站ClinicalTrials.Gov。研究结果集中于一旦出现认知症状即可缓解疾病,缓解疾病或缓解疾病的药物,以及治疗行为症状(如躁动)的药物,以及可预防高危认知能力下降的药物人们在诊断之前。

老年痴呆症'的疾病影响了近600万人 the United States and about 50 million globally. With a growing aging population, the Centers for Disease Control and Prevention projects the burden of 老年痴呆症's disease will nearly triple to 14 million people by 2060. New, effective treatments could delay the onset of 老年痴呆症'到5年后,到2050年,该疾病的患病人数和社会成本将分别减少约40%。

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